HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Methylmorpholine → N-[2-(3-methoxy-phenyl)-ethyl]-4-pentafluoroethyl-benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Methylmorpholine | HCID 7972 | — |
| Edukt | 3-Methoxyphenethylamine | HCID 74866 | — |
| Edukt | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Edukt | 4-(1,1,2,2,2-Pentafluoroethyl)benzoic acid | HCID 23067883 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N-[2-(3-methoxy-phenyl)-ethyl]-4-pentafluoroethyl-benzamide | HCID 86615231 | 96,1% |
Reaktionsschritte
A solution of 4-pentafluoroethyl-benzoic acid (500 mg, 2.08 mmol), 2-(3-methoxyphenyl)-ethylamine (361 mg, 2.29 mmol), 4-methylmorpholine (632 mg, 6.24 mmol), and HBTU (1.19 g, 3.12 mmol) in DMF (38 mL) was stirred at RT for 16 h, then the reaction mixture was partitioned between water and ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, heptane-ethyl acetate gradient) afforded the title compound (746 mg, 96%). Light yellow solid, MS (ISP) 374.2 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07678818B2 |
| Quelldatensatz | uspto-grants-2010_03 |
| ORD ID | ord-2a2903d4d33c421da9f5fda3104f999c |
| Quellennotiz | uspto-grants-2010_03 |