Aluminium lithium hydride → HCID 12878344, compound

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Reaction Steps

4 g of LiAlH4 are added in portions at 0° with stirring, and in an inert gas atmosphere, to 8.6 g of 4-(5-chloro-4-cyclohexyl-2-methoxyphenyl)-butyric acid methylester in 300 ml of anhydrous tetrahydrofuran. After 24 hours at 20°, the mixture is poured onto icecold NH4CL solution. The mixture is then acidified to pH=3 and extracted three times with ethyl acetate. The organic phases are washed once with water, dried over Na2SO4 and concentrated. The residue is distilled at 170°/0.5 mm.

Provenance & Evidence