Cesium carbonate → HCID 11617146, compound

Participants

Reaction Steps

Dry dioxane (1.00 ml) was added to a sealed microwave vial containing a mixture of 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) (0.015 g, 0.026 mmol), palladium dibenzylideneacetone chloroform complex (0.008 g, 0.008 mmol), 4-bromopyridine hydrochloride (0.03 g, 0.15 mmol), 5-amino-2-methyl-thiazole-4-carboxylic acid (3-chlorophenyl)-amide (0.05 g, 0.19 mmol) and cesium carbonate (0.18 g, 0.54 mmol). The mixture was stirred for 10 min, then irradiated in a microwave oven at 150° C. for 10 min. The volatiles were then removed under vacuum, and the residue was purified by flash chromatography (dichloromethane/methanol), yielding the title compound (0.005 g, 9%), as a yellow solid, MS (ISP): m/e=345.5 (M+H+).

Provenance & Evidence