Trifluoroacetic acid → HCID 58674938, compound

Participants

Reaction Steps

A solution of acetic acid 6-tert-butoxycarbonylamino-pyridin-2-ylmethyl ester (0.85 g, 3.18 mmol) in dichloromethane (30.00 ml) was cooled to 0° C. and trifluoroacetic acid (2.40 ml) was added dropwise. After stirring at room temperature for 3 h, further trifluoroacetic acid (1.50 ml) was added and stirring was maintained for further 2 h. The reaction mixture was basified with 1 N sodium bicarbonate (54.00 ml) to a pH 8. The organic phase was separated and the aqueous phase extracted twice with dichloromethane. The combined organic layers were dried over sodium sulphate and evaporated to yield pure acetic acid 6-amino-pyridin-2-ylmethyl ester (0.54 g, 100%) as a white solid, MS (ISP): m/e=167.4 (M+H+).

Provenance & Evidence