Aluminium lithium hydride → HCID 86606567, compound

Participants

Reaction Steps

A solution of 3-[4-(3-chloro-phenylcarbamoyl)-2-methyl-thiazol-5-ylamino]-benzoic acid methyl ester (0.02 g, 0.05 mmol) in THF (1.00 ml) was treated at room temperature with lithium aluminium hydride (0.008 g, 0.20 mmol) and stirred at room temperature for 30 min. The reaction mixture was quenched with a drop of 5N NaOH and sodium sulphate. The solids were filtered and the mother liquor evaporated. The residue was purified by flash chromatography (heptane/ethyl acetate) to yield the title compound (0.02 g, 90%) as a light brown gum.

Provenance & Evidence