Aluminium lithium hydride → HCID 86606569, compound

HRID 2244422Notes

Reaction equation

HRID 2244422 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:10][C:11]2[S:15][C:14]([CH3:16])=[N:13][C:12]=2[C:17](=[O:26])[NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=2)[CH:5]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:25][C:21]1[N:20]=[C:19]([NH:18][C:17]([C:12]2[N:13]=[C:14]([CH3:16])[S:15][C:11]=2[NH:10][C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([CH2:3][OH:2])[CH:5]=2)=[O:26])[CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 67549493HCID 67549493, compound

Product 1

HCID 86606569HCID 86606569, compound

Procedure

The title compound, MS (ISP): m/e=354.9 (M+H+), was prepared by reduction of 3-[2-methyl-4-(6-methyl-pyridin-2-ylcarbamoyl)-thiazol-5-ylamino]-benzoic acid methyl ester (prepared as illustrated in example 147) with lithium aluminium hydride, as described for example 142.

Sources & evidence

ORD record
ord-b96cdffadbec4978a697cd78ad9ea509
Source dataset
uspto-grants-2010_03
Patent number
US07678815B2

Reaction notes

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