Sodium Dithionite → Ethyl 2-amino-2-cyanoacetate

Participants

Reaction Steps

Cyano-hydroxyimino-acetic acid ethyl ester (30.00 g, 211.10 mmol) was added portionwise to a solution of water (766.00 ml) and saturated sodium bicarbonate (192.00 ml). Sodium dithionite (73.50 g, 422.00 mmol) was then added during 5 min. The mixture was stirred at room temperature for 2 hours, then extracted four times with dichloromethane. The combined organic extracts were dried with Na2SO4 and evaporated to afford aminocyanacetic acid ethyl ester as a light yellow oil (11.80 g, 44%).

Provenance & Evidence