Dicyclohexylcarbodiimide → HCID 86606570, compound

Participants

Reaction Conditions

Reaction Steps

A solution of aminocyanacetic acid ethyl ester (1.00 g, 7.80 mmol) in ethyl acetate (16.00 ml) was cooled to 0° C. and treated with dimethylaminopyridine (0.09 g, 0.78 mmol) and dicyclohexylcarbodiimide (1.93 g, 9.36 mmol). 3-Methoxy-propionic acid (0.81 g, 7.80 mmol) was added portionwise. After completed addition, the mixture was stirred at 0° C. for 1 h) then at room temperature for 3 h. The precipitated dicyclohexylurea was filtered off and the mother liquors washed with water, dried over sodium sulphate and evaporated. The residue was purified by trituration in diisopropylether to yield cyano-(3-methoxy-propionylamino)-acetic acid ethyl ester (1.27 g, 76%), MS (ISP): m/e=215.3 (M+H+).

Provenance & Evidence