Lawesson's reagent → HCID 68407298, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of cyano-(3-methoxy-propionylamino)-acetic acid ethyl ester (0.95 g, 4.44 mmol) in toluene (11.00 ml) was flushed with argon. 2,4-bis(4-Methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's reagent) (0.90 g, 2.22 mmol) was added at once and the mixture was warmed at 110° C. for 2 h. Toluene was evaporated and the residue purified by flash chromatography (heptane/ethyl acetate) to yield 5-amino-2-(2-methoxy-ethyl)-thiazole-4-carboxylic acid ethyl ester (0.42 g, 40%), MS (ISP): m/e=231.1 (M+H+).

Provenance & Evidence