HCID 68405954, compound → HCID 11631997, compound

Participants

Reaction Steps

The title compound, MS (ISP): m/e=366.0 (M+H+), was prepared as for example 153, steps A to G. Step C was performed using cyclobutanecarbonyl chloride, and yielded cyano-(cyclobutanecarbonyl-amino)-acetic acid ethyl ester, which was cyclized to 5-amino-2-cyclobutyl-thiazole-4-carboxylic acid ethyl ester in step D. This was used in step E to generate 2-cyclobutyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid ethyl ester, which was hydrolized to 2-cyclobutyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid in step F. Coupling as described in step G generated the title compound.

Provenance & Evidence