Ethyl 5-amino-2-isopropyl-1,3-thiazole-4-carboxylate → 2-Isopropyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide

Participants

Reaction Steps

The title compound, MS (ISP): m/e=352.3 (M+H+), was prepared as for example 153, steps A to G. Step C was performed using isobutyryl chloride, and yielded cyano-isobutyrylamino-acetic acid ethyl ester, which was cyclized to 5-amino-2-isopropyl-thiazole-4-carboxylic acid ethyl ester in step D. This was used in step E to generate 2-isopropyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid ethyl ester, which was hydrolized to 2-isopropyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid in step F. Coupling as described in step G generated the title compound.

Provenance & Evidence