Phosphorus tribromide → HCID 68452465, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) solution of (4-chloro-2-hydroxymethyl-phenoxy)-acetic acid methyl ester (5 g, 0.022 mmol) in DCM (50 mL) under an inert atmosphere of nitrogen is added phosphorus tribromide (1.03 mL, 0.011 mol) and the mixture is stirred at 0° C. for 90 minutes. The reaction mixture is diluted with water (15 mL) and allowed to warm to RT. The mixture is then washed with water (2×25 mL) and the organic portion is separated, washed with brine, dried (MgSO4) and concentrated in vacuo to yield the titled compound as a white solid.

Provenance & Evidence