反应详情

A solution comprising {4-chloro-2-[5-chloro-2-(1-methyl-2-oxo-2-pyrrolidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acid benzyl ester (63 mg, 0.116 mmol) in MeOH (1 mL) is treated with 2 M NaOH (145 μL) and allowed to stir at RT overnight. The resulting suspension is filtered, dissolved in water (1 mL) and the pH of the solution is adjusted to pH 1 using 2 M HCl. A precipitate forms which is filtered and dried in a vacuum oven to afford the titled product; MH+=452.

1. filtrationThe resulting suspension is filtered
2. dissolutiondissolved in water (1 mL)
3. filtrationA precipitate forms which is filtered
4. customdried in a vacuum oven