{4-Chloro-2-[5-chloro-2-(1-methyl-2-oxo-2-pyrrolidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acid → {4-Chloro-2-[2-(1-methyl-2-oxo-2-piperidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acid

HRID 2244478Notes

Reaction equation

HRID 2244478 reaction equation
ClC1C=CC(OCC(O)=O)=C(CC2C=C(Cl)C=CC=2OC(C)C(=O)N2CCCC2)C=1.C[O:32][C:33](=[O:61])[CH2:34][O:35][C:36]1[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][C:37]=1[CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[O:50][CH:51]([CH3:60])[C:52](=[O:59])[N:53]1[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54]1>>[Cl:42][C:39]1[CH:40]=[CH:41][C:36]([O:35][CH2:34][C:33]([OH:61])=[O:32])=[C:37]([CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=2[O:50][CH:51]([CH3:60])[C:52](=[O:59])[N:53]2[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54]2)[CH:38]=1

Participants

3

Reactant 2

HCID 11961250{4-Chloro-2-[5-chloro-2-(1-methyl-2-oxo-2-pyrrolidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acidHCID 68451410{4-Chloro-2-[2-(1-methyl-2-oxo-2-piperidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acid methyl ester

Product 1

HCID 11990635{4-Chloro-2-[2-(1-methyl-2-oxo-2-piperidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acid

Procedure

The titled compound is prepared analogously to {4-chloro-2-[5-chloro-2-(1-methyl-2-oxo-2-pyrrolidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acid (Example 1) by replacing {4-chloro-2-[5-chloro-2-(1-methyl-2-oxo-2-pyrrolidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acid benzyl ester with {4-chloro-2-[2-(1-methyl-2-oxo-2-piperidin-1-yl-ethoxy)-benzyl]-phenoxy}-acetic acid methyl ester; MH+=432.

Sources & evidence

ORD record
ord-1378c307d7b34f2bb5d6d3ae7df7c278
Source dataset
uspto-grants-2010_03
Patent number
US07678826B2

Reaction notes

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