HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylpiperidine → HCID 68452501, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylpiperidine | HCID 12291 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 68453158 | HCID 68453158 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68452501 | HCID 68452501 | — |
Reaction Steps
To a solution of [2-(2-benzyloxycarbonylmethoxy-5-chloro-benzyl)-4-chloro-phenoxy]-acetic acid (Intermediate C) (0.1 g, 0.211 mmol) in DCM (1 mL) is added DIPEA (37 μL, 0.211 mmol) and HATU (80 mg, 0.211 mmol). After stirring at RT for 1 hour, the reaction mixture is treated with 1-methyl piperidine (24 μL, 0.211 mmol) and allowed to stir at RT for 2 days. The resulting solution is purified by chromatography on silica eluting with EtOAc/MeOH (95:5) to yield the titled product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678826B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-5949d14e5af6473882d12b4413ba17a2 |
| Source note | uspto-grants-2010_03 |