HCID 68553217, compound → HCID 9924115, compound

Participants

Reaction Steps

4.67 g 4-dimethylamino-4-(3-fluorobenzyl)cyclohexanone were reacted with 1.0 molar benzylmagnesium chloride solution in THF analogously to the preparation of 4-dimethylamino-4-(4-fluorobenzyl)-1-phenethylcyclohexanol. After chromatography over silica gel, the nonpolar diastereoisomer of 1-benzyl-4-dimethylamino-4-(3-fluorobenzyl)cyclohexanol obtained was converted into 261 mg of the corresponding hydrochloride as described for example 4.

Provenance & Evidence