HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → Norquetiapine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-((2-Aminophenyl)thio)benzoic acid | HCID 10955828 | — |
| Product | Norquetiapine | HCID 11369918 | — |
Reaction Steps
simultaneously conducting cyclization and chlorination reactions of 2-(2-aminophenylthio)benzoic acid which is expressed by Formula 7 in an organic solvent in the presence of a halogenating agent and a base, and continuously reacting a resulting compound with piperazine without separation, to produce 11-piperazinyl-dibenzo[b,f][1,4]thiazepine expressed by Formula 4; and
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678902B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-817dfa2ae37e420e9488fec260172b8e |
| Source note | uspto-grants-2010_03 |