HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → Norquetiapine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-((2-Aminophenyl)thio)benzoic acid | HCID 10955828 | — |
| Product | Norquetiapine | HCID 11369918 | — |
Reaction Steps
Next, 2-(2-aminophenylthio)benzoic acid which is expressed by the above Formula 7 is simultaneously subjected to cyclization and chlorination reactions in the presence of a equivalent amount of halogenating agent and base in an organic solvent, and then reacted with piperazine without separation, to produce 11-piperazinyl-dibenzo[b,f][1,4]thiazepine expressed by the above Formula 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678902B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-530637aa1d654a4abfb42233554eb700 |
| Source note | uspto-grants-2010_03 |