HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Levofloxacin Hydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Levofloxacin | HCID 149096 | — |
| Reactant | Levofloxacin q-acid | HCID 688333 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Levofloxacin Hydrate | HCID 3033924 | — |
Reaction Steps
Accordingly in the present invention reacting (S)-(-) 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid with N-methyl piperazine yields crude levofloxacin. Suspending crude levofloxacin in isopropanol, addition of known quantity of water to make-up the water content to about 12% to about 20% followed by precipitation affords the levofloxacin hemihydrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678903B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-f8ece16a490046869f1ab8ccf68b4570 |
| Source note | uspto-grants-2010_03 |