Levofloxacin → Levofloxacin Hydrate

Participants

Reaction Steps

Levofloxacin crude is dissolved in mixture of toluene-chloroform at temperature of 20° C. to 40° C. by mixing for about 30 min to 2 hrs. Removed the insolubles by filtration, treated the clear solution with carbon and distilled off the toluene-chloroform at temperature below 60° C. Isopropanol is added to the mass, temperature is raised to 65° C. to 90° C., known quantity of water preferably to make-up the water content about 12% to about 20%, more selectively about 15% is added to the reaction mass at temperature of 60° C. to 90° C., mixed for about 5 min to 30 min, cooled to 15° C. to about 35° C., mixed for about 30 min to 4 hrs, isolated and dried at temperature of 45° C. to 85° C. preferably at 60° C. to 70° C. gives the levofloxacin hemihydrate.

Provenance & Evidence