HCID 72532772, compound → HCID 59214363, compound

Participants

Reaction Steps

N2-{[(5,6-Dichloropyridin-3-yl)carbonyl]oxy}-1H-indole-4-carboxamidine (1.91 g) was added to dioxane (40 ml), followed by heating under reflux for 5 hours. It was concentrated under reduced pressure, and then purified by silica gel column chromatography (EtOAc). To the obtained solid was added acetone, followed by suspension under heating. After being left to be cooled, the insolubles was collected by filtration to obtain 4-[5-(5,6-dichloropyridin-3-yl)-1,2,4-oxadiazol-3-yl]-1H-indole (1.44 g) as pale yellow powders.

Provenance & Evidence