HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → methyl N-(2-iodoethyl)-3-carbomethoxypyrrole-2-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | methyl N-(2-mesyloxyethyl)-3-carbomethoxypyrrole-2-acetate | HCID 12795003 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | methyl N-(2-iodoethyl)-3-carbomethoxypyrrole-2-acetate | HCID 12795009 | 97.3% |
Reaction Steps
A solution of 785 mg of methyl N-(2-mesyloxyethyl)-3-carbomethoxypyrrole-2-acetate and 1.83 g of sodium iodide in 10 ml of acetonitrile is refluxed for 1 hour. The cooled reaction mixture is evaporated to dryness under reduced pressure and the residue is triturated with water. The insoluble material is separated by filtration and is air dried, thus obtaining 840 mg (97%) of methyl N-(2-iodoethyl)-3-carbomethoxypyrrole-2-acetate (VI, R=H), m.p. 137°-138° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04232038 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-6182539114784b43bf875b3133e853f1 |
| Source note | uspto-grants-1980_11 |