1-(4-Aminophenyl)pyrazin-2(1H)-one → HCID 16066160, compound

Participants

Reaction Steps

In analogy to example 1C, (1R,3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-hydroxy-cyclopentanecarboxylic acid methyl ester (example 1B) was reacted with 1-(4-aminophenyl)-1H-pyrazin-2-one (CAS 444002-64-6) to give 5-chloro-thiophene-2-carboxylic acid {(1S,2S,4R)-2-hydroxy-4-[4-(2-oxo-2H-pyrazin-1-yl)-phenylcarbamoyl]-cyclopentyl}-amide. Light yellow solid. MS: 459.3 ([M+H]+)

Provenance & Evidence