Iodoethane → HCID 58826421, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (1R,3S,4S)-3-azido-4-hydroxy-cyclopentanecarboxylic acid methyl ester (500 mg) at r.t. in acetonitrile/THF 3:1 (8 ml) under an argon atmosphere were added Ag2O (1.88 g) and ethyl iodide (2.18 ml). The black suspension was stirred for 18 h at 60° C., then cooled to r.t. The black solid was filtered off and washed with ethyl acetate. The filtrate was concentrated. The crude product was purified by column chromatography (silica gel; gradient: cyclohexane→cyclohexane/EtOAc 7:3) to give (1R,3S,4S)-3-azido-4-ethoxy-cyclopentanecarboxylic acid methyl ester (474 mg) as light yellow oil. MS: 214.1 ([M+H]+).

Provenance & Evidence