HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-thiophenecarboxylic acid → HCID 68685554, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| Reactant | HCID 86611034 | HCID 86611034 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Product | HCID 68685554 | HCID 68685554 | — |
Reaction Steps
In analogy to example 10A and example 1B, (S,4S)-3-azido-4-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-cyclopentanecarboxylic acid methyl ester was hydrogenated in the presence of PtO2 and coupled with 5-chloro-2-thiophenecarboxylic acid to give (3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-cyclopentanecarboxylic acid methyl ester. Brown gum. MS 432.2 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678917B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-90f33a30689a4e96952aac6a990b0956 |
| Source note | uspto-grants-2010_03 |