Chloroform ethanol → (1SR,3RS,4SR)-3-aminomethyl-4-methoxy-cyclopentanecarboxylic acid methyl ester hydrochloride

Participants

Reaction Steps

To a stirred solution of (1SR,3RS,4SR)-3-cyano-4-methoxy-cyclopentanecarboxylic acid methyl ester (595 mg) in ethanol/chloroform 5:1 (6 ml) was added PtO2 (60 mg). The reaction mixture was hydrogenated overnight. The catalyst was filtered off and washed with MeOH. The filtrate was concentrated to give (1SR,3RS,4SR)-3-aminomethyl-4-methoxy-cyclopentanecarboxylic acid methyl ester hydrochloride (704 mg) as white amorphous semisolid. MS 188.3 ([M+H]+).

Provenance & Evidence