Methanesulfonyl chloride → HCID 58826441, compound

HRID 2244699Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([N:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]2=[O:14])[CH:5]=[CH:4][C:3]=1[NH:15][C:16]([CH:18]1[CH2:22][CH:21]([CH2:23][NH:24][C:25]([C:27]2[S:28][C:29]([Cl:32])=[CH:30][CH:31]=2)=[O:26])[CH:20]([NH:33][CH3:34])[CH2:19]1)=[O:17].[CH3:35][S:36](Cl)(=[O:38])=[O:37]>>[F:1][C:2]1[CH:7]=[C:6]([N:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]2=[O:14])[CH:5]=[CH:4][C:3]=1[NH:15][C:16]([CH:18]1[CH2:22][CH:21]([CH2:23][NH:24][C:25]([C:27]2[S:28][C:29]([Cl:32])=[CH:30][CH:31]=2)=[O:26])[CH:20]([N:33]([S:36]([CH3:35])(=[O:38])=[O:37])[CH3:34])[CH2:19]1)=[O:17]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 58826475HCID 58826475, compound

Product 1

HCID 58826441HCID 58826441, compound

Procedure

In analogy to example 26 5-chloro-thiophene-2-carboxylic acid {4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-2-methylamino-cyclopentylmethyl}-amide (example 33) was reacted with methane sulfonylchloride to give 5-chloro-thiophene-2-carboxylic acid [4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-2-(methanesulfonyl-methyl-amino)-cyclopentylmethyl]-amide. Light yellow solid. 581.2 ([M+H]+).

Sources & evidence

ORD record: ord-656f18dc2fd3450dacf77851c746fc63
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07678917B2

Reaction notes

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