Cyclohexylamine → HCID 12777837, compound

Participants

Reaction Steps

A mixture of 2-chloro-9-(2-cyclohexenyl)-9H-adenine (300 mg., 1.2 mmole) and 1 ml. of cyclohexylamine in 3 ml. of ethanol is heated at 120°-125° C. for a period of 89 hrs. in a sealed tube and then evaporated in vacuo to give an oil. Purification of residual oil by column chromatography on silica gel affords 288 mg (77%) of 9-(2-cyclohexenyl)-2-cyclohexylamino-9H-adenine, m.p. 108°-111° C. IR (KBr): 3315, 3170, 2925, 2845, 1630, 1600, 1530, 1470, 1405 cm-1. UV: λmaxEtoH 224 nm(ε26,500), 259 nm(ε11,100), 291 nm(ε9,900). NMR(CDCl3): δ 0.9-2.3(16H,m), 3.75(1H,br.s), 4.95(1H,br.s), 5.4-6.2(2H,m), 7.42(1H,s).

Provenance & Evidence