HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Difluoro-3-prop-2-ynyloxybenzene → 7,8-Difluorochroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Difluoro-3-prop-2-ynyloxybenzene | HCID 59215238 | — |
| Reactant | 7,8-difluoro-2H-chromene | HCID 59215287 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7,8-Difluorochroman | HCID 59167323 | — |
Reaction Steps
A mixture of 7,8-difluoro-2H-chromene and 1,2-difluoro-3-prop-2-ynyloxybenzene (43.2 g) is hydrogenated at 20° C. for 1 h in 430 ml of THF in the presence of Pd/C (5% Pd). The batch is concentrated to dryness, and the crude product is purified by column chromatography (SiO2, n-pentane:1-chlorobutane=4:1), giving pure 7,8-difluorochroman as a slightly yellowish liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678929B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-2a4772ec68c74d99834b5f6da0e0d033 |
| Source note | uspto-grants-2010_03 |