HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1-Ethynylhexyloxy)-2,3-difluorobenzene → 7,8-difluoro-2-pentyl-2H-chromene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1-Ethynylhexyloxy)-2,3-difluorobenzene | HCID 59215239 | — |
| Solvent | N,N-Diethylaniline | HCID 7061 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 7,8-difluoro-2-pentyl-2H-chromene | HCID 59215273 | — |
Reaction Steps
62.0 g (0.26 mol) of 1-(1-ethynylhexyloxy)-2,3-difluorobenzene are heated at 195° C. for 2 h in 390 ml of N,N-diethylaniline. The batch is diluted with MTBE and washed a number of times with 1 N HCl. The organic phase is dried using sodium sulfate and concentrated to dryness. The residue is purified by column chromatography (SiO2, n-pentane:1-chlorobutane=5:1), giving 7,8-difluoro-2-pentyl-2H-chromene as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678929B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-92890d6f913a42d7ac51efd2a663901f |
| Source note | uspto-grants-2010_03 |