Sodium Hydroxide → 2-(2-Ethylsulfanyl-1-methoxy-1-methyl-ethyl)-5-nitro-6-trifluoromethyl-1H-indole

HRID 2244863Notes

Reaction equation

HRID 2244863 reaction equation
[CH2:1]([S:3][CH2:4][C:5]([C:9]1[N:10](S(C)(=O)=O)[C:11]2[C:16]([CH:17]=1)=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=2)([O:7][CH3:8])[CH3:6])[CH3:2].[OH-].[Na+]>>[CH2:1]([S:3][CH2:4][C:5]([C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[C:13]([C:21]([F:23])([F:22])[F:24])[CH:12]=2)([O:7][CH3:8])[CH3:6])[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 116263392-(2-ethylsulfanyl-1-methoxy-1-methyl-ethyl)-1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indole

Product 1

HCID 115450402-(2-Ethylsulfanyl-1-methoxy-1-methyl-ethyl)-5-nitro-6-trifluoromethyl-1H-indole

Procedure

This compound was prepared using the general de-protection procedure, as described in General Procedures Example. The starting material used was 2-(2-ethylsulfanyl-1-methoxy-1-methyl-ethyl)-1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indole (0.17 g, 0.39 mmol). The base used was 4N sodium hydroxide (0.19 mL, 0.77 mmol). The title compound was obtained as a yellow solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c8a7c3a4d73f47d383a5c336875b0f8a
Source dataset
uspto-grants-2010_03
Patent number
US07678926B2

Reaction notes

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