Sodium Hydroxide → 2-(5-Nitro-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl)-butan-2-ol

HRID 2244868Notes

Reaction equation

HRID 2244868 reaction equation
CS([N:5]1[C:13]2[C:8](=[CH:9][C:10]([N+:18]([O-:20])=[O:19])=[C:11]([C:14]([F:17])([F:16])[F:15])[CH:12]=2)[CH:7]=[C:6]1[C:21]([OH:31])([CH2:29][CH3:30])[CH2:22][S:23][CH2:24][C:25]([F:28])([F:27])[F:26])(=O)=O.[OH-].[Na+]>>[N+:18]([C:10]1[CH:9]=[C:8]2[C:13](=[CH:12][C:11]=1[C:14]([F:15])([F:16])[F:17])[NH:5][C:6]([C:21]([OH:31])([CH2:29][CH3:30])[CH2:22][S:23][CH2:24][C:25]([F:28])([F:27])[F:26])=[CH:7]2)([O-:20])=[O:19]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 115041752-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl)-butan-2-ol

Product 1

HCID 115897432-(5-Nitro-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl)-butan-2-ol

Procedure

This compound was prepared using the standard de-protection procedure, as described in General Procedure Example B, starting from 2-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl) -butan-2-ol (0.65 g, 1.31 mmol) and using 4N sodium hydroxide as base (1 mL, 4.0 mmol) to yield the title compound as a solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-60d6ffba082f4f7db318e471e742ace5
Source dataset
uspto-grants-2010_03
Patent number
US07678926B2

Reaction notes

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