Sodium Hydroxide → 1-Butylsulfanyl-2-(5-nitro-6-trifluoromethyl-1H-indol-2-yl)-propan-2-ol

HRID 2244874Notes

Reaction equation

HRID 2244874 reaction equation
[CH2:1]([S:5][CH2:6][C:7]([C:10]1[N:11](S(C)(=O)=O)[C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([N+:19]([O-:21])=[O:20])=[C:14]([C:22]([F:25])([F:24])[F:23])[CH:13]=2)([OH:9])[CH3:8])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([S:5][CH2:6][C:7]([C:10]1[NH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([N+:19]([O-:21])=[O:20])=[C:14]([C:22]([F:24])([F:25])[F:23])[CH:13]=2)([OH:9])[CH3:8])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 115905691-butylsulfanyl-2-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-propan-2-ol

Product 1

HCID 116250001-Butylsulfanyl-2-(5-nitro-6-trifluoromethyl-1H-indol-2-yl)-propan-2-ol

Procedure

This compound was prepared using the general de-protection procedure as describe in General Procedures Example B. The starting material used was 1-butylsulfanyl-2-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl) -propan-2-ol (0.53 g, 1.16 mmol). The base that was used was 4N sodium hydroxide solution (1 mL, 4 mmol). The title compound was obtained as a yellow sticky oil.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-324003d9cfe74068ae427617ed17eea8
Source dataset
uspto-grants-2010_03
Patent number
US07678926B2

Reaction notes

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