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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2244900Generated: November 1, 2026

Hydrochloric Acid → HCID 59212647, compound

https://huagongshe.com/reaction/2244900

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 59212645HCID 59212645—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 59212647HCID 59212647152.9%

Reaction Steps

tert-Butyl 4-methyl-4-{(3S)-3-methyl-4-[6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl}piperidine-1-carboxylate (0.32 g, 0.6 mmol) was dissolved in a 4 M; solution of HCl in dioxane (8.0 mL). After being stirred at room temperature for 2 hrs, the solution was concentrated to give the title compound (0.35 g) as a trihydrochloride salt. MS calculated for C21H30F3N3: (M+H)+ 382; found 382.2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07678798B2
Source datasetuspto-grants-2010_03
ORD IDord-69d82911eedf4b1cadeb3b0d2e8c5146
Source noteuspto-grants-2010_03