HCID 86761066, compound → HCID 59212642, compound

Participants

Reaction Steps

tert-Butyl 4-{(3S)-4-[(1R,2R)-2-hydroxy-5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-3-methylpiperazin-1-yl}-4-methylpiperidine-1-carboxylate [(1R)-7,7-dimethyl-2-oxobicyclo [2.2.1]hept-1-yl]methanesulfonic acid salt (512 g, 0.701 mol) was dissolved in 1 M aqueous sodium hydroxide (1 L), and the solution was extracted with methylene chloride (2×2 L). The combined organic layers were dried over magnesium sulfate and concentrated. The residue was further dried under high vacuum to give off-white foamy solid (346 g. 99.1%). MS (EI) 498.2 (M+1).

Provenance & Evidence