反应详情

To a solution of 4-bromo-6,6a-dihydro-1aH-indeno[1,2-b]oxirene (247.9 mg, 1.1746 mmol) in ethanol (10.00 mL) was added tert-butyl 4-methyl-4-[(3S)-3-methylpiperazin-1-yl]piperidine-1-carboxylate (349.36 mg, 1.1746 mmol). The reaction mixture was heated to reflux overnight. After cooling down, the mixture was evaporated under reduced pressure. Purification on silica gel with 50% ethyl acetate (1% NH4OH) and hexane afforded the fast moving product as the desired compound (295 mg; 49.4%).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux overnight
3. temperatureAfter cooling down
4. customthe mixture was evaporated under reduced pressure
5. customPurification on silica gel with 50% ethyl acetate (1% NH4OH) and hexane
6. customafforded the