Dimethylformamide → HCID 11668908, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	4-Chlorophenyl Isocyanate	HCID 7693	—
Reactant	Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate	HCID 151348	—
Reactant	N-o-Fluorophenylglycine	HCID 5171030	—
Reactant	tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)	HCID 45072188	—
Solvent	Water	HCID 962	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	HCID 11668908	HCID 11668908	—

Reaction Steps

To a solution of 2-fluorophenylglycine (59 mg, 0.35 mmol) in DMF (4 mL), 4-chlorophenylisocyanate (54 mg, 0.35 mmol) was added. The mixture was stirred at room temperature overnight. To the solution, a solution of N-BOC-aminomethylpiperidine hydrochloride (105 mg, 0.42 mmol) and TEA (0.150 mL, 1.08 mmol) in DMF (4 mL) was added, followed by addition of BOP (239 mg, 0.54 mmol). The mixture was then stirred at room temperature overnight. EtOAc and H2O were added. The organic layer was separated, dried over Na2SO4, concentrated in vacuo.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07678913B2
Source dataset	uspto-grants-2010_03
ORD ID	ord-fef33255059a4f9590e7a6568b4ed735
Source note	uspto-grants-2010_03