Ethanol → HCID 86606527, compound

HRID 2244978Notes

Reaction equation

HRID 2244978 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9](=[O:29])[CH:10]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[F:28])[NH:11][C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)=[O:13])[CH2:3][CH2:2]1.Cl.[C:31](=[NH:36])([O:33]CC)[CH3:32].CC[OH:39]>>[C:32]1(=[O:39])[N:36]([N:1]2[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9](=[O:29])[CH:10]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[F:28])[NH:11][C:12]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)=[O:13])[CH2:3][CH2:2]2)[C:31]1=[O:33]

Participants

4

Reactant 3

HCID 702EthanolHCID 2724290Ethanimidic acid, ethyl ester, hydrochloride (1:1)HCID 11668908HCID 11668908, compound

Product 1

HCID 86606527HCID 86606527, compound

Procedure

A solution of N-(piperidin-4-ylmethyl)-2-(2-fluorophenyl)-2-(4-chlorophenylaminocarbonylamino)-acetamide (from EXAMPLE 53, 70 mg, 0.17 mmol), ethyl acetimidate hydrochloride (40 mg, 0.32 mmol) and TEA (0.070 mL, 0.50 mmol) in EtOH (3 mL) was stirred at room temperature overnight. It was then concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a white powder (37 mg). MS 460.1 and 462.1 (M+H, Cl pattern).

Workup

  1. concentrationIt was then concentrated in vacuo
  2. customThe residue was purified by HPLC

Sources & evidence

ORD record
ord-f7b7306f6025408db16e973c146ce21b
Source dataset
uspto-grants-2010_03
Patent number
US07678913B2

Reaction notes

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