Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → N-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-(2-bromophenyl)-2-(4-chlorophenylaminocarbonylamino)-acetamide

Participants

Reaction Steps

To a solution of 2-(2-bromophenyl)-2-(4-chlorophenylaminocarbonylamino)-acetic acid (from EXAMPLE 77, 30 mg, 0.078 mmol), 1-(1-methylpiperidin-4-yl)piperazine (purchased from Oakwood products, 21 mg, 0.11 mmol) and TEA (0.0-44 mL, 0.31 mmol) in DMF (3 mL), BOP (69 mg, 0.16 mmol) was added. After being stirred at room temperature for 1 h, the mixture was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a powder (39 mg). MS 548.3 and 550.3 (M+H, Cl+Br pattern).

Provenance & Evidence