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1,2-Dichloroethane → N-[4-(thiazolidin-3-ylcarbonyl)phenyl]-2-(2-methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dichloroethane | HCID 11 | — |
| 反応物 | 2-(2-Methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetic acid | HCID 68689841 | — |
| 反応物 | 4-(3-Thiazolidinylcarbonyl)phenylamine | HCID 68693033 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[4-(thiazolidin-3-ylcarbonyl)phenyl]-2-(2-methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetamide | HCID 11713190 | 21% |
反応手順
To a solution of 2-(2-methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetic acid (46 mg, 0.14 mmol) and 4-(thiazolidin-3-ylcarbonyl)phenylamine (30 mg, 0.14 mmol) in DMF (2 mL), EDC (54 mg, 0.28 mmol) was added. The reaction mixture was stirred at room temperature overnight. It was then concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a white powder (15 mg). MS 509.2 and 511.2 (M+H, Cl pattern).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07678913B2 |
| 出典データセット | uspto-grants-2010_03 |
| ORD ID | ord-2e8fc0ed925540a5b43f38b9984809d0 |
| 出典メモ | uspto-grants-2010_03 |