Water → HCID 68692671, compound

Participants

Reaction Steps

To a solution of the solid (110 mg, 0.866 mmol) in 1N aq. NaOH (3 mL), a solution of 4-chlorophenyl isocyanate (200 mg, 1.30 mmol) in dioxane (3 mL) was added. The mixture was stirred at room temperature for 16 h. H2O (20 mL) was added. The aqueous layer was washed with Et2O, acidified with 4N HCl to pH 1-2. The product was extracted with EtOAc. The EtOAc solution was dried over Na2SO4, concentrated in vacuo. The residue was purified by HPLC to give the urea acid as a white powder (207 mg). MS 303.3 and 305.2 (M+Na, Cl pattern)

Provenance & Evidence