Acetic Acid → HCID 68694848, compound

Participants

Reaction Steps

To the thioimidate solution in MeOH (4 mL, 0.063 mmol) from Example 134, a pre-mixed pyrrolidine (0.037 mL, 0.44 mmol) and HOAc (0.040 mL, 0.70 mmol) were added. The mixture was heated to reflux for 1 h, then was stirred at room temperature overnight. After being concentrated in vacuo, the residue was purified by HPLC to give a white powder (15 mg). MS 488.3 and 490.3 (M+H, Cl pattern).

Provenance & Evidence