HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-(2-Piperidinon-1-yl)piperidin-1-yl-2-phenyl-2-(4-chlorophenylaminocarbonylamino)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | N-(tert-Butoxycarbonyl)-N-phenylglycine | HCID 21905636 | — |
| Reactant | [1,4']Bipiperidinyl-2-one hydrochloride | HCID 23138456 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(2-Piperidinon-1-yl)piperidin-1-yl-2-phenyl-2-(4-chlorophenylaminocarbonylamino)-acetamide | HCID 69572876 | — |
Reaction Steps
To a solution of(D) N-BOC phenylglycine (32 mg, 0.13 mmol), 4-(2-piperidinon-1-yl)piperidine hydrochloride (22 mg, 0.10 mmol) and triethylamine (0.070 mL, 0.50 mmol) in DMF (1.0 mL), BOP (66 mg, 0.15 mmol) was added. The mixture was stirred at room temperature for 20 min. Water and EtOAc were added. The EtOAc phase was separated, washed with 5% NaHCO3, dried over Na2SO4, and concentrated in vacuo to give the amide (51 mg). MS 416.5 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678913B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-b0a4a27eeb07448abfc79007e1225c0a |
| Source note | uspto-grants-2010_03 |