HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 2245007Erstellt: 25. Oktober 2026
1,2-Diaminocyclohexane, trans- → 4-Methyl-1-(4-pyridinyl)-2-piperazinone
https://huagongshe.com/reaction/2245007
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1,2-Diaminocyclohexane, trans- | HCID 43806 | — |
| Edukt | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Edukt | 4-Iodopyridine | HCID 609492 | — |
| Edukt | 1-Methyl-3-oxopiperazine | HCID 13704283 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 4-Methyl-1-(4-pyridinyl)-2-piperazinone | HCID 21050559 | 23,6% |
Reaktionsschritte
A mixture of 4-iodopyridine (218 mg, 1.06 mmol), 4-methyl-2-piperazinone (106 mg, 0.929 mmol), K3PO4 (425 mg, 2.00 mmol) and 1,2-trans-diaminocyclohexane (0.050 mL, 0.41 mmol) in anhydrous dioxane (3.0 mL) was degassed with Ar before being charged with CuI (40 mg, 0.21 mmol). The mixture in a sealed tube was heated at 110 ° C. overnight. The mixture was purified by a prep-TLC using MeOH/CH2Cl2 (10/90) as solvents to give 1-(pyridin-4-yl)-4-methyl-2-piperazinone (42 mg). MS 192.5 (M+H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07678913B2 |
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| Quelldatensatz | uspto-grants-2010_03 |
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| ORD ID | ord-a0527ae04f854423940e08ddd03c311b |
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| Quellennotiz | uspto-grants-2010_03 |
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