N-Isopropylethylenediamine → 3-[8-(2,6-difluorophenyl)-2-({2-[(1-methylethyl)amino]ethyl}amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-1,3-thiazol-2-ylbenzamide

Participants

Reaction Steps

The title compound was prepared from 3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-1,3-thiazol-2-ylbenzamide and N-(1-methylethyl)-1,2-ethanediamine by following the procedures in Example 79c. LC-MS m/z 576 (M+H)+; 1H-NMR (MeOD) 1.02 (d, J=6.0 Hz, 6 H), 2.31 (m, 3 H), 2.72 (m, 3 H), 3.23 (m, 1 H), 3.55 (m, 1 H), 6.36 (d, J=8.8 Hz, 1 H), 7.13 (m, 1 H), 7.24 (m, 2 H), 7.47 (m, 2 H), 7.56 (m, 2 H), 8.00 (s, 1 H), 8.10 (d, J=7.6 Hz, 1 H).

Provenance & Evidence