HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-chloro-8-(2,6-difluorophenyl)-2-(4-methyl-1,4'-bipiperidin-1'-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Methyl-1,4'-bipiperidine | HCID 795715 | — |
| Reactant | 4-chloro-8-(2,6-difluorophenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one | HCID 11951514 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-chloro-8-(2,6-difluorophenyl)-2-(4-methyl-1,4'-bipiperidin-1'-yl)pyrido[2,3-d]pyrimidin-7(8H)-one | HCID 11951519 | 51% |
Reaction Conditions
| Temperature | -20 °C |
|---|
Reaction Steps
To the compound 4-chloro-8-(2,6-difluorophenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one (1.39 g, 3.9 mmol) in dichloromethane (80 mL) were added 4-methyl-1,4′-bipiperidine (0.75 g, 5.85 mol) and triethylamine (1.03 mL, 11.7 mmol). The mixture was stirred at −20° C. overnight. Filtration followed by concentration, the crude was purified with flash chromatography to afford the title compound (0.904 g, 51%). LC-MS m/z 474 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678801B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-1e9d442c2ce04977afb2aa1fc2bdfb2d |
| Source note | uspto-grants-2010_03 |