2-Hydrazinoethanol → Ethyl 1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

Compound 5 was prepared using the classical approach for preparing pyrazoles [7]. Ethyl 2-formyl-3-oxopropionate (2.80 g; 20 mmol) was dissolved in 20 ml of ethanol and cooled to 0° C. 2-Hydroxyethylhydrazine (1.44 g; 20 mmol) was dissolved in 100 ml of ethanol and was added dropwise to the solution of ethyl 2-formyl-3-oxopropionate. The reaction mixture was left overnight at room temperature. The solvent was vacuum removed yielding a yellow oil. Yield: 95%

Provenance & Evidence