HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2245231Generated: October 26, 2026
Acetonitrile → Isobutyl 4-(2-(2-hydroxyphenyl)pyridin-4-yl)piperazine-1-carboxylate
https://huagongshe.com/reaction/2245231
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol | HCID 2734622 | — |
| Reactant | Isobutyl 4-(2-chloropyridin-4-yl)piperazine-1-carboxylate | HCID 58853192 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Water | HCID 962 | — |
| Product | Isobutyl 4-(2-(2-hydroxyphenyl)pyridin-4-yl)piperazine-1-carboxylate | HCID 135547506 | — |
Reaction Steps
2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol (25/μL, 120 μmol), 3a (30 mg, 100 μmol), Pd(Ph3P)4 (12 mg, 10 μmol), K2CO3 (28 mg, 200 μmol), CH3CN (900 μL), and H2O (100 μL) were sealed in a microwave vessel and heated by microwave irradiation at 120° C. for 15 minutes. The reaction was filtered and purified by reverse phase HPLC to give compound 1. (10%-99% CH3CN/H2O), (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA). LCMS: m/z 356.1 (M+H)+ at 2.24 minutes (10%-99% CH3CN/H2O), (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07683065B2 |
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| Source dataset | uspto-grants-2010_03 |
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| ORD ID | ord-f70556166651423a8db3cdd77edd78e8 |
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| Source note | uspto-grants-2010_03 |
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