HCID 86628107, compound → HCID 86628109, compound

Participants

Reaction Steps

To a solution of the crude oil from Step M in 50 mL ethanol was added 0.2 g (20% by weight) of 10% Pd(OH)2—C. The mixture was hydrogenated at 50 PSi for 16 hr at room temperature. The catalyst was filtered through a filter aid pad. The solvent of the filtrate was removed under vacuum to give the title compound (0.35 g). 1H-NMR (CDCl3) δ: 7.70 (1H, s), 7.23 (2H, m), 7.21 (2H, s), 6.98 (2H, m), 4.48 (1H, q, J=6.5 Hz), 4.15 (2H, m), 3.27 (1H, m), 2.86 (2H, m), 2.53 (1H, d, J=11.0 Hz), 2.36 (1H, m), 2.07 (3H, s), 1.98 (2H, m), 1.75 (1H, m), 1.55-1.27 (2H, m), 1.37 (3H, d, J=6.4 Hz). MS: (MH)+ 536.5.

Provenance & Evidence