HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 59216593, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 23262449 | HCID 23262449 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59216593 | HCID 59216593 | — |
Reaction Steps
To a solution of 5-nitroquinolin-3-ol in DMF is added sodium hydride at 0° C. Then, methyl iodide is added and the mixture is stirred for 2 h. Water is added and the mixture is extracted with ethyl acetate. The organic layer is dried, filtered and concentrated under reduced pressure to give 3-methoxy-5-nitroquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07683076B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-c11d1320af24428ea695ebab90f7259e |
| Source note | uspto-grants-2010_03 |